Interaction of MSC with tumor cells. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Melzer, Catharina; Yang, Yuanyuan; Hass, Ralf
• Is Part Of: Cell communication and signaling. Volume 14:Issue 1(2016)
• Page Start: 1
• Page End: 12
• Publication Date: 2016-12
• Subjects: MSC -- Mesenchymal stroma/stem cells -- Tumor cell signaling -- Tumor microenvironment -- Cellular interaction -- Cell fusion; Cell interaction -- Periodicals; 571.6
• DOI: 10.1186/s12964-016-0143-0
• Languages: English
• ISSNs: 1478-811X

Abstract

Abstract Tumor development and tumor progression is not only determined by the corresponding tumor cells but also by the tumor microenvironment. This includes an orchestrated network of interacting cell types (e.g. immune cells, endothelial cells, fibroblasts, and mesenchymal stroma/stem cells (MSC)) via the extracellular matrix and soluble factors such as cytokines, chemokines, growth factors and various metabolites. Cell populations of the tumor microenvironment can interact directly and indirectly with cancer cells by mutually altering properties and functions of the involved partners. Particularly, mesenchymal stroma/stem cells (MSC) play an important role during carcinogenesis exhibiting different types of intercellular communication. Accordingly, this work focusses on diverse mechanisms of interaction between MSC and cancer cells. Moreover, some functional changes and consequences for both cell types are summarized which can eventually result in the establishment of a carcinoma stem cell niche (CSCN) or the generation of new tumor cell populations by MSC-tumor cell fusion.