Inhibitory effects of benzimidazole containing new phenolic Mannich bases on human carbonic anhydrase isoforms hCA I and II. (1st November 2016)

• Record Type: Journal Article
• Authors: Gul, Halise Inci; Yazici, Zehra; Tanc, Muhammet; Supuran, Claudiu T.
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 31:Number 6(2016:Dec.)
• Page Start: 1540
• Page End: 1544
• Publication Date: 2016-11-01
• Subjects: Benzimidazole -- carbonic anhydrase -- enzyme inhibition -- Mannich bases -- phenol; Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.3109/14756366.2016.1156675
• Languages: English
• ISSNs: 1475-6366

Abstract

Abstract: New phenolic mono and bis Mannich bases incorporating benzimidazole, such as 2-(aminomethyl)-4-(1 H -benzimidazol-2-yl)phenol and 2, 6-bis(aminomethyl)-4-(1 H -benzimidazol-2-yl)phenol were synthesized starting from 4-(1 H -benzimidazol-2-yl)phenol. Amines used for the synthesis included dimethylamine, pyrrolidine, piperidine, N -methylpiperazine and morpholine. The CA inhibitory properties of these compounds were tested on the human carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I and hCA II. These new compounds, as many phenols show moderate CA inhibitory properties.