REM sleep behavior disorder was associated with Parkinson's disease: a community-based study. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Ma, Jian-Fang; Hou, Miao-Miao; Tang, Hui-Dong; Gao, Xiang; Liang, Liang; Zhu, Li-Fang; Zhou, Yi; Zha, Sheng-Yu; Cui, Shi-Shuang; Du, Juan-Juan; Li, Gen; Liu, Jun; Chen, Sheng-Di
• Is Part Of: BMC neurology. Volume 16:Issue 1(2016)
• Page Start: 1
• Page End: 7
• Publication Date: 2016-12
• Subjects: Community-based study -- Parkinson's disease -- Prevalence -- REM sleep behavior disorder; Neurology -- Periodicals; 616.8005
• DOI: 10.1186/s12883-016-0640-1
• Languages: English
• ISSNs: 1471-2377

Abstract

Abstract Background Our study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD (p RBD) in a rural community based on RBD1Q-C and investigate the association betweenp RBD and Parkinson's disease (PD). Methods The validation study of RBD1Q-C included 32 Chinese participants (14 idiopathic RBD patients and 18 controls). All participants underwent a polysomnogram (PSG). We then conducted a door-to-door survey to estimate the prevalence ofp RBD assessed by RBD1Q-C, and its association with PD among 19614 residents who lived in Malu community of Shanghai, China. Results RBD1Q-C demonstrated a high sensitivity of 100 %, a moderate specificity of 55.6 %. The agreement between RBD1Q-C and PSG-based RBD diagnosis was good (k = 0.552). PPV of the RBD1Q-C was 63.6 % and NPV was 100 %. The prevalence ofp RBD in Malu community was 4.9 %. In people over 50 years old, presence ofp RBD was significantly associated with increased risk of having PD (odds ratio = 2.61, 95 % CI: 1.56–4.39). Conclusion RBD1Q-C was shown to be a useful screening tool. Based on the RBD1Q-C, we found thatp RBD was not rare in Chinese rural population and associated with odds of PD, calling for more attention from patients, caregivers and physicians.