Nucleophosmin: from structure and function to disease development. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Box, Joseph; Paquet, Nicolas; Adams, Mark; Boucher, Didier; Bolderson, Emma; O'Byrne, Kenneth; Richard, Derek
• Is Part Of: BMC molecular biology. Volume 17:Issue 1(2016)
• Page Start: 1
• Page End: 12
• Publication Date: 2016-12
• Subjects: Nucleophosmin 1 -- DNA repair -- Cancer -- Apoptosis; Molecular biology -- Periodicals; 572.805
• DOI: 10.1186/s12867-016-0073-9
• Languages: English
• ISSNs: 1471-2199

Abstract

Abstract Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular biology as is underlined in cancer where NPM1 is commonly overexpressed, mutated, rearranged and sporadically deleted. Consistent with a multifunctional role within the cell, NPM1 can function not only as a proto-oncogene but also as a tumor suppressor. The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers.