Β-glucans: ex vivo inflammatory and oxidative stress results after pasta intake. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Barera, Annalisa; Buscemi, Silvio; Monastero, Roberto; Caruso, Calogero; Caldarella, Rosalia; Ciaccio, Marcello; Vasto, Sonya
• Is Part Of: Immunity & ageing. Volume 13:Issue 1(2016)
• Page Start: 1
• Page End: 6
• Publication Date: 2016-12
• Subjects: Mediterranean diet -- β-glucans -- Diet -- Inflammation -- Oxidative stress; Aging -- Immunological aspects -- Periodicals; 618.97079
• DOI: 10.1186/s12979-016-0068-x
• Languages: English
• ISSNs: 1742-4933

Abstract

Abstract Background It is well known that Mediterranean Diet can positively influence the health of each individual, in particular it is know that fibers have an important role. However, in Mediterranean cities most people do not have a close adherence to Mediterranean diet. Thus, in our study, we considered fibers like β-glucans that have been added to pasta with a percentage of 6 %. Our study aimed to evaluate the capacity of β-glucans intake on oxidative stress and inflammation in a cohort of middle aged slightly overweight subjects. Methods We used a longitudinal study design. The study lasted 30 days during which time, each participant acted with no food restriction. Participants underwent morning fasting blood venous sample for blood chemistry and other biological parameters at the beginning of the study and after 30 days of pasta supplemented with 6 % of β-glucan intake 4 times a week. We performed anthropometric, biochemical, oxidative stress and cytokine analysis at the beginning and the end of study. Results After the 30 days of pasta intake we obtained a significant decrease of LDL-cholesterol, IL-6 and AGEs levels. Conclusion The results confirmed a capacity of β-glucans intake to lower oxidative stress. Additional longitudinal observation on community-based cohorts are needed to confirm these data and investigate the biological mechanisms through which effects are induced, and to fully explore the therapeutic potential of β-glucans.