BAG2 structure, function and involvement in disease. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Qin, Lixia; Guo, Jifeng; Zheng, Qian; Zhang, Hainan
• Is Part Of: Cellular & molecular biology letters. Volume 21:Issue 1(2016)
• Page Start: 1
• Page End: 11
• Publication Date: 2016-12
• Subjects: BAG2 -- Molecular chaperones -- Carcinoma -- Alzheimer's disease -- Parkinson's disease -- Spinocerebellar ataxia type-3; Cytology -- Periodicals; Molecular biology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Cells -- Periodicals; Molecular Biology -- Periodicals; Physiology -- Periodicals; 571.605
• DOI: 10.1186/s11658-016-0020-2
• Languages: English
• ISSNs: 1425-8153

Abstract

Abstract Bcl2-associated athanogene 2 (BAG2) shares a similar molecular structure and function with other BAG family members. Functioning as a co-chaperone, it interacts with the ATPase domain of the heat shock protein 70 (dHsp70) through its BAG domain. It also interacts with many other molecules and regulates various cellular functions. An increasing number of studies have indicated that BAG2 is involved in the pathogenesis of various diseases, including cancers and neurodegenerative diseases. This paper is a comprehensive review of the structure, functions, and protein interactions of BAG2. We also discuss its roles in diseases, including cancer, Alzheimer's disease, Parkinson's disease and spinocerebellar ataxia type-3. Further research on BAG2 could lead to an understanding of the pathogenesis of these disorders or even to novel therapeutic approaches.