Cuff Leak Test for the Diagnosis of Post-Extubation Stridor: A Multicenter Evaluation Study. (May 2019)

• Record Type: Journal Article
• Authors: Schnell, David; Planquette, Benjamin; Berger, Asaël; Merceron, Sybille; Mayaux, Julien; Strasbach, Lucas; Legriel, Stéphane; Valade, Sandrine; Darmon, Michael; Meziani, Ferhat
• Is Part Of: Journal of intensive care medicine. Volume 34:Number 5(2019)
• Page Start: 391
• Page End: 396
• Publication Date: 2019-05
• Subjects: endotracheal intubation -- cuff leak test -- post-extubation stridor -- sensitivity -- evaluation; Critical care medicine -- Periodicals; Critical Care -- Periodicals; Soins intensifs -- Périodiques; Soins intensifs; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.02805
• DOI: 10.1177/0885066617700095
• Languages: English
• ISSNs: 0885-0666

Abstract

Background: Cuff leak test was developed to predict the occurrence of post-extubation stridor (PES). This study evaluated the diagnostic performance of this test in unselected critically ill patients. Methods: Multicenter prospective study including unselected ventilated patients at the time of their first planned extubation. The diagnostic performance of 4 different cuff leak tests was assessed. Results: Post-extubation stridor occurred in 34 (9.4%) of 362 included patients. Compared to patients without PES, patients with PES required more frequently reintubation (6 [17.6%] vs 26 [7.9%], P = .041), prolonged duration of ventilation (6 [3-13] vs 5 [2-9] days, P = .029), and longer intensive care unit (ICU) stay (12 [6-17.5] vs 7.5 [4-13] days, P = .018). However, ICU mortality was similar in both groups (1 [2.9%] vs 23 [7.0%], P = .61). The 4 cuff leak tests display poor diagnostic accuracy: sensitivities ranging from 27% to 46%, specificities from 70% to 88%, positive predictive values from 14% to 19%, and negative predictive values from 92% to 93%. Conclusion: Post-extubation stridor occurs in less than 10% of unselected critically ill patients. The several cuff leak tests display limited diagnostic performance for the detection of PES. Given the high rate of false positives, routine cuff leak test may expose to undue prolonged mechanical ventilation.