Antidiabetic properties of dietary flavonoids: a cellular mechanism review. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Vinayagam, Ramachandran; Xu, Baojun
• Is Part Of: Nutrition & metabolism. Volume 12:Issue 1(2015)
• Page Start: 1
• Page End: 20
• Publication Date: 2015-12
• Subjects: Dietary flavonoids -- Diabetes mellitus -- Glycemic control -- Insulin secretion -- Hyperglycemia; Nutrition -- Periodicals; Metabolism -- Periodicals; 612.39
• DOI: 10.1186/s12986-015-0057-7
• Languages: English
• ISSNs: 1743-7075

Abstract

Abstract Background Natural food products have been used for combating human diseases for thousands of years. Naturally occurring flavonoids including flavones, flavonols, flavanones, flavonols, isoflavones and anthocyanidins have been proposed as effective supplements for management and prevention of diabetes and its long-term complications based onin vitro and animal models. Aim To summarize the roles of dietary flavonoids in diabetes management and their molecular mechanisms. Findings Tremendous studies have found that flavonoids originated from foods could improve glucose metabolism, lipid profile, regulating the hormones and enzymes in human body, further protecting human being from diseases like obesity, diabetes and their complications. Conclusion In the current review, we summarize recent progress in understanding the biological action, mechanism and therapeutic potential of the dietary flavonoids and its subsequent clinical outcomes in the field of drug discovery in management of diabetes mellitus.