Macrolide resistance in pneumococci—is it relevant?. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Cheng, Allen; Jenney, Adam
• Is Part Of: Pneumonia. Volume 8:Issue 1(2016)
• Page Start: 1
• Page End: 3
• Publication Date: 2016-12
• Subjects: Streptococcus pneumoniae -- Antibiotic resistance -- Macrolides -- Community-acquired pneumonia; Pneumonia -- Periodicals; 616.241
• DOI: 10.1186/s41479-016-0010-1
• Languages: English
• ISSNs: 2200-6133

Abstract

Abstract Macrolide antibiotics are widely used for a range of indications, including pneumonia. Both high-level and low-level resistance to macrolides is increasing in pneumococci globally. Macrolide resistance in pneumococci is of limited clinical relevance where ß-lactams remain the mainstay of treatment, such as for moderate/severe pneumonia; however, data suggest that macrolides may not be able to be relied on as monotherapy for serious pneumococcal infections.