The case for using digital EEG analysis in clinical sleep medicine. Issue 1 (December 2017)

• Record Type: Journal Article
• Authors: Younes, Magdy
• Is Part Of: Sleep science and practice. Volume 1:Issue 1(2017)
• Page Start: 1
• Page End: 15
• Publication Date: 2017-12
• Subjects: Sleep depth -- Arousal intensity -- Alpha intrusion -- Sleep spindles -- K Complexes -- Odds ratio product -- ORP -- Michele sleep scoring; Sleep -- Physiological aspects -- Periodicals; Sleep -- Periodicals; Sleep disorders -- Periodicals; Sleep disorders -- Treatment -- Periodicals; 612.82105
• DOI: 10.1186/s41606-016-0005-0
• Languages: English
• ISSNs: 2398-2683

Abstract

Abstract Evaluation of sleep in clinical polysomnograms continues to rely almost exclusively on visual scoring that implements rules proposed by Rechtschaffen and Kales nearly 50 years ago. Apart from its cost and time-consuming nature, visual scoring has limitations including: A) Sleep depth, which is a continuous variable, is treated as if it changes in a stepwise fashion from light (stage 1), to intermediate (stage 2) to deep (stage 3). B) Even with this limited scale, there is considerable inter-scorer variability, particularly in scoring stages 1 and 3 of non-REM sleep, thereby adding uncertainty to %time spent in these stages as a reliable metric for evaluating sleep depth. C) Limitation in scoring some of EEG features, including 1) arousal intensity, 2) extent of Alpha intrusion and 3) frequency, and characteristics of sleep spindles and K complexes. Digital analysis can solve these problems but producing a reliable system has been a challenge. In this review I begin with recent advances in digital scoring of sleep according to the Rechtschaffen and Kales rules and conclude that this technology has progressed enough to make it possible to obtain reliable, reproducible scoring, comparable in accuracy to scoring by highly experienced technologists, with minimal editing. This is followed by description of several new metrics that can be obtained if digital scoring systems were to be used routinely in clinical studies. The scientific evidence supporting the potential of these metrics to positively impact sleep medicine practice and the wide range of such metrics in patients studied in the sleep laboratory are highlighted.