Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies. Issue 1 (December 2017)

• Record Type: Journal Article
• Authors: Qureshi-Baig, Komal; Ullmann, Pit; Haan, Serge; Letellier, Elisabeth
• Is Part Of: Molecular cancer. Volume 16:Issue 1(2017)
• Page Start: 1
• Page End: 16
• Publication Date: 2017-12
• Subjects: Colorectal cancer -- Cancer stem cells -- Tumor-initiating cells -- Culturing conditions -- Surface markers -- Spheroid Culture Systems -- Metabolic identity -- Targeted therapy -- Inter- and intra-tumor heterogeneity; Cancer -- Molecular aspects -- Periodicals; 616.994
• DOI: 10.1186/s12943-017-0602-2
• Languages: English
• ISSNs: 1476-4598

Abstract

Abstract Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapies. Despite significant advances in TIC biology, their isolation and identification remain largely disputed and incompletely established. In this review, we discuss the latest developments in isolation and culturing approaches of TICs, with focus on colorectal cancer (CRC). We feature recent findings on TIC-relevant signaling pathways and the metabolic identity of TICs, as well as their current clinical implications. Lastly, we highlight the influence of inter- and intra-tumoral heterogeneity on TIC function and targeting approaches.