Use of ethanol extracts of Terminalia chebula to prevent periodontal disease induced by dental plaque bacteria. Issue 1 (December 2017)

• Record Type: Journal Article
• Authors: Lee, Jongsung; Nho, Youn; Yun, Seok; Hwang, Young
• Is Part Of: BMC complementary and alternative medicine. Volume 17:Issue 1(2017)
• Page Start: 1
• Page End: 10
• Publication Date: 2017-12
• Subjects: Ethanol extract of Terminalia chebula (EETC) -- Gingivitis -- Periodontitis -- Dental plaque bacteria (DPB) -- Lipopolysaccharide (LPS) -- Inflammation -- Osteoclast; Alternative medicine -- Periodicals; Complementary Therapies -- Periodicals; 615.505
• DOI: 10.1186/s12906-017-1619-1
• Languages: English
• ISSNs: 1472-6882

Abstract

Abstract Background The fruit of theTerminalia chebula tree has been widely used for the treatment of various disorders. Its anti-diabetic, anti-mutagenic, anti-oxidant, anti-bacterial, anti-fungal, and anti-viral effects have been studied. Dental plaque bacteria (DPB) are intimately associated with gingivitis and periodontitis. In the quest for materials that will prove useful in the treatment and prevention of periodontal disease, we investigated the preventive effects of an ethanol extract ofTerminalia chebula (EETC) on DPB-induced inflammation and bone resorption. Methods The anti-bacterial effect of EETC was analyzed using the disc diffusion method. The anti-inflammatory effect of EETC was determined by molecular biological analysis of the DPB-mediated culture cells. Prevention of osteoclastic bone resorption by EETC was explored using osteoclast formation and pit formation assays. Results EETC suppressed the growth of oral bacteria and reduced the induction of inflammatory cytokines and proteases, abolishing the expression of PGE2 and COX-2 and inhibiting matrix damage. By stimulating the DPB-derived lipopolysaccharides, EETC inhibited both osteoclast formation in osteoclast precursors and RANKL expression in osteoblasts, thereby contributing to the prevention of bone resorption. Conclusions EETC may be a beneficial supplement to help prevent DPB-mediated periodontal disease.