Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in complete Freund's adjuvant-induced arthritis in rats. Issue 1 (December 2017)

• Record Type: Journal Article
• Authors: Mbiantcha, Marius; Almas, Jabeen; Shabana, Simjee; Nida, Dastagir; Aisha, Faheem
• Is Part Of: BMC complementary and alternative medicine. Volume 17:Issue 1(2017)
• Page Start: 1
• Page End: 16
• Publication Date: 2017-12
• Subjects: Piptadeniastrum africanum -- Immunomodulation -- Oxidative burst -- T-cell proliferation -- Cytotoxicity -- Rheumatoid arthritis; Alternative medicine -- Periodicals; Complementary Therapies -- Periodicals; 615.505
• DOI: 10.1186/s12906-017-1623-5
• Languages: English
• ISSNs: 1472-6882

Abstract

Abstract Background Rheumatoid arthritis, disease of unknown causes is a rheumatic and autoimmune pathology, recognised for its increasing frequency and its adverse consequences. It is a disease that occurs in most cases between 50 and 60 years and women are more affected than men. This study aimed at evaluating immunomodulatory and anti-arthritis capacity of aqueous and methanol extracts of stem bark ofPiptadeniastrum africanum (Mimosaceae). Methods ROS production from phagocytes, proliferation of T-cells, TNF-α and IL-1β production and cytotoxicity were performed by using chemiluminescence technique, liquid scintillation counter, ELISA and MTT assay, respectively. Anti-arthritic activity was evaluated using a model of adjuvant induced arthritis. Results Methanol and aqueous extracts ofPiptadeniastrum africanum significantly (P < 0.001 ) inhibited extracellular and intracellular ROS production. These extracts also possess significant (P < 0.001 ) inhibitory activity on T-cell proliferation other than reduced TNF-α and IL-1β production.Piptadeniastrum africanum also significantly exhibited antiarthritic activity in complete Freund's adjuvant induced arthritis in rat associated with a significant anti-inflammatory and anti-hyperalgesia activity. Conclusions Immunomodulatory, anti-inflammatory, antihyperalgesia and anti-arthritis potential revealed in this study approve that, Piptadeniastrum africanum is a plant rich in compounds with anti-arthritic properties.