C-peptide is independent associated with diabetic peripheral neuropathy: a community-based study. Issue 1 (December 2017)

• Record Type: Journal Article
• Authors: Qiao, Xiaona; Zheng, Hangping; Zhang, Shuo; Liu, Siying; Xiong, Qian; Mao, Fei; Zhang, Zhaoyun; Wen, Jie; Ye, Hongying; Li, Yiming; Lu, Bin
• Is Part Of: Diabetology & metabolic syndrome. Volume 9:Issue 1(2017)
• Page Start: 1
• Page End: 7
• Publication Date: 2017-12
• Subjects: Diabetic peripheral neuropathy -- C-peptide -- Beta-cell function -- Community-based; Diabetes -- Pathophysiology -- Periodicals; Metabolic syndrome -- Periodicals; 616.462005
• DOI: 10.1186/s13098-017-0208-2
• Languages: English
• ISSNs: 1758-5996

Abstract

Abstract Background Because the relationship between C-peptide and diabetic peripheral neuropathy (DPN) is controversial, the aim of our study was to evaluate the relationship between C-peptide and DPN in community-based Chinese patients with type 2 diabetes. Methods In total, 220 consecutive type 2 diabetic patients treated by our regional medical consortium were enrolled. DPN was assessed by clinical symptoms, signs, and electromyography. Results Fasting C-peptide, 2-h postprandial C-peptide and ΔC-peptide (i.e., 2-h postprandial C-peptide minus the fasting C-peptide) serum concentrations in the non-DPN group were significantly higher than those in the clinical DPN group (allP ≤ 0.040) and the confirmed DPN group (allP < 0.002). The three C-peptide parameters were independently associated with DPN (allP < 0.05) after adjusting for age, sex, diabetes duration, smoking status, systolic pressure, body mass index, angiotensin-converting enzyme inhibitors/angiotensin receptor blocker use, fasting plasma glucose, HbA1c, triglyceride and estimated glomerular filtration rate. Compared with the ΔC-peptide quartile 1 (reference), patients in quartile 3 (odds ratio [OR], 0.110; 95% confidence interval [CI] 0.026–0.466;P = 0.003) and quartile 4 (OR, 0.012; 95% CI 0.026–0.559;P = 0.007) had a lower risk of DPN after adjusting for the confounders. Conclusions C-peptide was negatively associated with DPN in community-based Chinese type 2 diabetic patients in China.