Blood pressure and acute kidney injury. Issue 1 (December 2017)

• Record Type: Journal Article
• Authors: Sato, Ryota; Luthe, Sarah; Nasu, Michitaka
• Is Part Of: Critical care. Volume 21:Issue 1(2017)
• Page Start: 1
• Page End: 2
• Publication Date: 2017-12
• Subjects: Acute kidney injury -- Central venous pressure -- Mean arterial pressure -- Mean perfusion pressure -- Diastolic perfusion pressure; Critical care medicine -- Periodicals; 616.02805
• DOI: 10.1186/s13054-017-1611-7
• Languages: English
• ISSNs: 1364-8535

Abstract

Abstract Maintaining the optimal blood pressure is an important aspect of preventing acute kidney injury (AKI), especially for vasopressor-dependent patients. Although mean arterial pressure (MAP) has played an important role in previous trials for prevention of AKI, there is little evidence that MAP actually reflects organ perfusion. In fact, several studies have suggested that perfusion pressure, including diastolic perfusion pressure and mean perfusion pressure (MPP) and calculated with central venous pressure (CVP), may be more useful than the widely used MAP to help prevent AKI. This emphasizes the importance of maintaining diastolic arterial pressure and avoiding elevation of CVP to prevent AKI in patients with sepsis or invasive surgery. To achieve this, further investigation regarding titrated fluid therapy and vasopressors is warranted.