Toward precision medicine of breast cancer. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Carels, Nicolas; Spinassé, Lizânia; Tilli, Tatiana; Tuszynski, Jack
• Is Part Of: Theoretical biology and medical modelling. Volume 13:Issue 1(2016)
• Page Start: 1
• Page End: 46
• Publication Date: 2016-12
• Subjects: Hallmarks -- Omics -- Profiling -- Therapy -- Stem cell -- Signaling networks -- Tumor heterogeneity -- Pharmacogenetics; Biology -- Mathematical models -- Periodicals; Biology -- Periodicals; Medical sciences -- Periodicals; 570.15118
• DOI: 10.1186/s12976-016-0035-4
• Languages: English
• ISSNs: 1742-4682

Abstract

Abstract In this review, we report on breast cancer's molecular features and on how high throughput technologies are helping in understanding the dynamics of tumorigenesis and cancer progression with the aim of developing precision medicine methods. We first address the current state of the art in breast cancer therapies and challenges in order to progress towards its cure. Then, we show how the interaction of high-throughput technologies within silico modeling has led to set up useful inferences for promising strategies of target-specific therapies with low secondary effect incidence for patients. Finally, we discuss the challenge of pharmacogenetics in the clinical practice of cancer therapy. All these issues are explored within the context of precision medicine.