Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Bhoo-Pathy, Nirmala; Peeters, Petra; Uiterwaal, Cuno; Bueno-de-Mesquita, H; Bulgiba, Awang; Bech, Bodil; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Clavel-Chapelon, Françoise; Fagherazzi, Guy; Perquier, Florence; Teucher, Birgit; Kaaks, Rudolf; Schütze, Madlen; Boeing, Heiner; Lagiou, Pagona; Orfanos, Philippos; Trichopoulou, Antonia; Agnoli, Claudia; Mattiello, Amalia; Palli, Domenico; Tumino, Rosario; Sacerdote, Carlotta; van Duijnhoven, Franzel; Braaten, Tonje; Lund, Eiliv; Skeie, Guri; Redondo, María-Luisa; Buckland, Genevieve; Pérez, Maria; Chirlaque, Maria-Dolores; Ardanaz, Eva; Amiano, Pilar; Wirfält, Elisabet; Wallström, Peter; Johansson, Ingegerd; Nilsson, Lena; Khaw, Kay-Tee; Wareham, Nick; Allen, Naomi; Key, Timothy; Rinaldi, Sabina; Romieu, Isabelle; Gallo, Valentina; Riboli, Elio; van Gils, Carla;
• Is Part Of: Breast cancer research. Volume 17:Issue 1(2015)
• Page Start: 1
• Page End: 12
• Publication Date: 2015-12
• Subjects: Breast -- Cancer -- Periodicals; 616.99449
• DOI: 10.1186/s13058-015-0521-3
• Languages: English
• ISSNs: 1465-542X

Abstract

Abstract Introduction Specific coffee subtypes and tea may impact risk of pre- and post-menopausal breast cancer differently. We investigated the association between coffee (total, caffeinated, decaffeinated) and tea intake and risk of breast cancer. Methods A total of 335, 060 women participating in the European Prospective Investigation into Nutrition and Cancer (EPIC) Study, completed a dietary questionnaire from 1992 to 2000, and were followed-up until 2010 for incidence of breast cancer. Hazard ratios (HR) of breast cancer by country-specific, as well as cohort-wide categories of beverage intake were estimated. Results During an average follow-up of 11 years, 1064 premenopausal, and 9134 postmenopausal breast cancers were diagnosed. Caffeinated coffee intake was associated with lower risk of postmenopausal breast cancer: adjusted HR = 0.90, 95% confidence interval (CI): 0.82 to 0.98, for high versus low consumption;P trend = 0.029. While there was no significant effect modification by hormone receptor status (P = 0.711), linear trend for lower risk of breast cancer with increasing caffeinated coffee intake was clearest for estrogen and progesterone receptor negative (ER-PR-), postmenopausal breast cancer (P = 0.008). For every 100 ml increase in caffeinated coffee intake, the risk of ER-PR- breast cancer was lower by 4% (adjusted HR: 0.96, 95% CI: 0.93 to 1.00). Non-consumers of decaffeinated coffee had lower risk of postmenopausal breast cancer (adjusted HR = 0.89; 95% CI: 0.80 to 0.99) compared to low consumers, without evidence of dose–response relationship (P trend = 0.128). Exclusive decaffeinated coffee consumption was not related to postmenopausal breast cancer risk, compared to any decaffeinated-low caffeinated intake (adjusted HR = 0.97; 95% CI: 0.82 to 1.14), or to no intake of any coffee (HR: 0.96; 95%: 0.82 to 1.14). Caffeinated and decaffeinated coffee were not associated with premenopausal breast cancer. Tea intake was neither associated with pre- nor post-menopausal breast cancer. Conclusions Higher caffeinated coffee intake may be associated with lower risk of postmenopausal breast cancer. Decaffeinated coffee intake does not seem to be associated with breast cancer.