Practical considerations for the use of mTOR inhibitors. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Diekmann, Fritz; Campistol, Josep
• Is Part Of: Transplantation research. Volume 4:Issue 1(2015)
• Page Start: 13
• Page End: 17
• Publication Date: 2015-12
• Subjects: Calcineurin inhibitors -- mTOR-inhibitors -- Nephrotoxicity -- Post-transplant malignancy -- Kidney transplantation; Transplantation of organs, tissues, etc -- Periodicals; 617.954
• DOI: 10.1186/s13737-015-0029-5
• Languages: English
• ISSNs: 2047-1440

Abstract

Abstract Immunosuppressive therapy after kidney transplantation is based on calcineurin inhibitors (CNI). In most cases CNI therapy is combined with mycophenolate and steroids. In spite of good short-term results this therapy is associated with long-term toxicities, graft loss and patient death. Therefore, alternative immunosuppressive strategies are needed that combine excellent efficacy with low incidences of long-term adverse outcomes. This review focuses on the strategies based on mTOR- inhibitors in combination with minimized exposure to CNI.