18F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Kobayashi, Shigeki; Ogura, Mayumi; Suzawa, Naohisa; Horiki, Noriyuki; Katsurahara, Masaki; Ogura, Toru; Sakuma, Hajime
• Is Part Of: BMC medical imaging. Volume 16:Issue 1(2016)
• Page Start: 1
• Page End: 8
• Publication Date: 2016-12
• Subjects: 18F-FDG PET/CT -- Helicobacter pylori infection -- Chronic atrophic gastritis; Diagnostic imaging -- Periodicals; 616.075405
• DOI: 10.1186/s12880-016-0161-9
• Languages: English
• ISSNs: 1471-2342

Abstract

Abstract Background The aim of this study was to determine the value of18 F-FDG uptake on screening PET/CT images for the prediction ofHelicobacter pylori (H. pylori ) infection and chronic atrophic gastritis. Methods Among subjects who underwent18 F-FDG PET/CT for cancer screening from April 2005 to November 2015, PET/CT images were analyzed in 88 subjects who had gastrointestinal fiberscopy within 6 months. The volumes of interest (VOIs) were placed in the fornix, corpus and antrum of the stomach to determine maximal standardized uptake value (SUVmax) and mean SUV (SUVmean). Receiver operating characteristic curve (ROC) analysis was performed to determine the diagnostic performance of SUV indicators in predictingH. pylori infection and chronic atrophic gastritis. Results SUV indicators of the stomach were significantly higher in subjects withH. pylori infection than those without (fromP < 0.001 toP < 0.05). ROC analysis revealed that SUVmean had the highest performance in predictingH. pylori infection (AUC 0.807) and chronic atrophic gastritis (AUC 0.784). SUVmean exhibited the sensitivity of 86.5 % and the specificity of 70.6 % in predictingH. pylori infection, and the sensitivity of 75.0 % and 78.6 % in predicting chronic atrophic gastritis. Conclusion Assessment of18 F-FDG uptake in the stomach reflecting active inflammation is useful in predicting patients withH. pylori infection and subsequent chronic atrophic gastritis which is closely associated with the risk of gastric neoplasms.