Prospective, randomized comparison of gadopentetate and gadobutrol to assess chronic myocardial infarction applying cardiovascular magnetic resonance. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Rudolph, Andre; Messroghli, Daniel; von Knobelsdorff-Brenkenhoff, Florian; Traber, Julius; Schüler, Johannes; Wassmuth, Ralf; Schulz-Menger, Jeanette
• Is Part Of: BMC medical imaging. Volume 15:Issue 1(2015)
• Page Start: 1
• Page End: 10
• Publication Date: 2015-12
• Subjects: Cardiovascular Magnetic Resonance -- Contrast media -- Gadobutrol -- Gd-DTPA -- Chronic myocardial infarction -- Late gadolinium enhancement; Diagnostic imaging -- Periodicals; 616.075405
• DOI: 10.1186/s12880-015-0099-3
• Languages: English
• ISSNs: 1471-2342

Abstract

Abstract Background We hypothesized that the contrast medium gadobutrol is not inferior compared to Gd-DTPA in identifying and quantifying ischemic late gadolinium enhancement (LGE), even by using a lower dose. Methods We prospectively enrolled 30 patients with chronic myocardial infarction as visualized by LGE during clinical routine scan at 1.5 T with 0.20 mmol/kg Gd-DTPA. Participants were randomized to either 0.15 mmol/kg gadobutrol (group A) or 0.10 mmol/kg gadobutrol (group B). CMR protocol was identical in both exams. LGE was quantified using a semiautomatic approach. Signal intensities of scar, remote myocardium, blood and air were measured. Signal to noise (SNR) and contrast to noise ratios (CNR) were calculated. Results Signal intensities were not different between Gd-DTPA and gadobutrol in group A, whereas significant differences were detected in group B. SNR of injured myocardium (53.5+/−21.4 vs. 30.1+/−10.4, p = 0.0001) and CNR between injured and remote myocardium (50.3+/−20.3 vs. 27.3+/−9.3, p < 0.0001) were lower in gadobutrol. Infarct size was lower in both gadobutrol groups compared to Gd-DTPA (group A: 16.8+/−10.2 g vs. 12.8+/−6.8 g, p = 0.03; group B: 18.6+/−12.0 g vs. 14.0+/−9.9 g, p = 0.0016). Conclusions Taking application of 0.2 mmol/kg Gd-DTPA as the reference, the delineation of infarct scar was similar with 0.15 mmol/kg gadobutrol, whereas the use 0.10 mmol/kg gadobutrol led to reduced tissue contrast. Trial registration The study had been registered under EudraCT Number:2010-020775-22 . Registration date: 2010.08.10