Immunotherapeutic approaches to ovarian cancer treatment. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Chester, Cariad; Dorigo, Oliver; Berek, Jonathan; Kohrt, Holbrook
• Is Part Of: Journal for immunotherapy of cancer. Volume 3:Issue 1(2015)
• Page Start: 1
• Page End: 10
• Publication Date: 2015-12
• Subjects: Ovarian cancer -- ID8 -- Antibody -- TAM -- Immune checkpoint blockade -- IDO -- Cancer vaccine -- ACT; Cancer -- Immunotherapy -- Periodicals; Cancer -- Immunological aspects -- Periodicals; Tumors -- Immunological aspects -- Periodicals; Immunotherapy -- Periodicals; 616.99406105
• DOI: 10.1186/s40425-015-0051-7
• Languages: English
• ISSNs: 2051-1426

Abstract

Abstract Despite advances in combinatorial chemotherapy regimens and the advent of intraperitoneal chemotherapy administration, current therapeutic options for ovarian cancer patients are inadequate. Immunotherapy offers a novel and promising therapeutic strategy for treating ovarian tumors. Following the demonstration of the immunogenicity of ovarian tumors, multiple immunotherapeutic modalities have been developed. Antibody-based therapies, immune checkpoint blockade, cancer vaccines, and chimeric antigen receptor-modified T cells have demonstrated preclinical success and entered clinical testing. In this review, we discuss these promising immunotherapeutic approaches and emphasize the importance of combinatorial treatment strategies and biomarker discovery.