Association between GDF5 +104T/C polymorphism and knee osteoarthritis in Caucasian and Asian populations: a meta-analysis based on case-control studies. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Jiang, Dong; Hao, Zengtao; Fan, Dongsheng; Guo, Wen; Xu, Pengcheng; Yin, Chao; Wen, Shuzheng; Wang, Jihong
• Is Part Of: Journal of orthopaedic surgery and research. Volume 11:Issue 1(2016)
• Page Start: 1
• Page End: 7
• Publication Date: 2016-12
• Subjects: Meta-analysis -- Osteoarthritis -- Polymorphism -- GDF5; Orthopedics -- Periodicals; Orthopedic surgery -- Periodicals; 616.7005
• DOI: 10.1186/s13018-016-0436-4
• Languages: English
• ISSNs: 1749-799X

Abstract

Abstract Background Osteoarthritis (OA) is a degenerative joint disease with a complex genetic background. Variants in growth differentiation factor 5 (GDF5 ) have been reported to be associated with rheumatoid arthritis (RA) in several ethnic populations. The present study aimed to assess the association between theGDF5 +104T/C polymorphism and the susceptibility of the knee to OA through a meta-analysis of available case-control studies. Methods The PubMed and Science Direct citation databases were used to search electronic literature in order to identify studies published between January 2007 and July 2016 that evaluated the association between theGDF5 +104T/C polymorphism and the susceptibility of the knee to OA. Different genetic models were used to assess the pooled and stratified data. Results A positive association was found in all pooled studies (OR = 0.808, 95 % CI = 0.754–0.866, p < 0.001). Regarding genotypes, significant associations were found using a dominant model (OR = 0.777, 95 % CI = 0.708–0.852, p < 0.001), a recessive model (OR = 0.723, 95%CI = 0.623–0.839, p < 0.001), and an additive model (CC vsTT OR = 0.648, 95 % CI = 0.552–0.760, p < 0.001;CC vsCT OR = 0.801, 95 % CI = 0.685–0.936, p = 0.005). Meta-analysis data were stratified by ethnicity, and theGDF5 C allele was found to be positively associated with OA of the knee in both Caucasians and Asians, as were theGDF5 TC andCC genotypes. In addition, using an additive model, theCC genotype was found to be significantly associated with OA of the knee in both Caucasians and Asians when comparingCC vsTT genotypes, but not in Caucasians when comparingTT vsCT genotypes. Conclusions Meta-analysis results indicated that theGDF5 +104T/C polymorphism is a protective factor for OA among Caucasian and Asian populations.