Analyzing myocardial torsion based on tissue phase mapping cardiovascular magnetic resonance. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Chitiboi, Teodora; Schnell, Susanne; Collins, Jeremy; Carr, James; Chowdhary, Varun; Honarmand, Amir; Hennemuth, Anja; Linsen, Lars; Hahn, Horst; Markl, Michael
• Is Part Of: Journal of cardiovascular magnetic resonance. Volume 18:Issue 1(2016)
• Page Start: 1
• Page End: 13
• Publication Date: 2016-12
• Subjects: Non-ischemic cardiomyopathy -- Myocardial velocities -- Torsion -- Cardiovascular magnetic resonanace -- Tissue phase mapping; Cardiovascular system -- Magnetic resonance imaging -- Periodicals; 616.1207548
• DOI: 10.1186/s12968-016-0234-5
• Languages: English
• ISSNs: 1097-6647

Abstract

Abstract Background The purpose of this work is to analyze differences in left ventricular torsion between volunteers and patients with non-ischemic cardiomyopathy based on tissue phase mapping (TPM) cardiovascular magnetic resonance (CMR). Methods TPM was performed on 27 patients with non-ischemic cardiomyopathy and 14 normal volunteers. Patients underwent a standard CMR including late gadolinium enhancement (LGE) for the assessment of myocardial scar and ECG-gated cine CMR for global cardiac function. TPM was acquired in short-axis orientation at base, mid, and apex for all subjects. After evaluation by experienced observers, the patients were divided in subgroups according to the presence or absence of LGE (LGE+/LGE-), local wall motion abnormalities (WM+/WM-), and having a preserved (≥50 %) or reduced (<50 %) ejection fraction (EF+/EF-). TPM data was semi-automatically segmented and global LV torsion was computed for each cardiac time frame for endocardial and epicardial layers, and for the entire myocardium. Results Maximum myocardial torsion was significantly lower for patients with reduced EF compared to controls (0.21 ± 0.15°/mm vs. 0.36 ± 0.11°/mm, p = 0.018), but also for patients with wall motion abnormalities (0.21 ± 0.13°/mm vs. 0.36 ± 0.11°/mm, p = 0.004). Global myocardial torsion showed a positive correlation (r = 0.54, p < 0.001) with EF. Moreover, endocardial torsion was significantly higher than epicardial torsion for EF+ subjects (0.56 ± 0.33°/mm vs. 0.34 ± 0.18°/mm, p = 0.039) and for volunteers (0.46 ± 0.16°/mm vs. 0.30 ± 0.09°/mm, p = 0.004). The difference in maximum torsion between endo- and epicardial layers was positively correlated with EF (r = 0.47, p = 0.002) and age (r = 0.37, p = 0.016) for all subjects. Conclusions TPM can be used to detect significant differences in LV torsion in patients with reduced EF and in the presence of local wall motion abnormalities. We were able to quantify torsion differences between the endocardium and epicardium, which vary between patient subgroups and are correlated to age and EF.