Myocardial triglyceride content at 3 T cardiovascular magnetic resonance and left ventricular systolic function: a cross-sectional study in patients hospitalized with acute heart failure. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Liao, Pen-An; Lin, Gigin; Tsai, Shang-Yueh; Wang, Chao-Hung; Juan, Yu-Hsiang; Lin, Yu-Ching; Wu, Ming-Ting; Yang, Lan-Yan; Liu, Min-Hui; Chang, Tsun-Ching; Lin, Yu-Chun; Huang, Yu-Chieh; Huang, Pei-Ching; Wang, Jiun-Jie; Ng, Shu-Hang; Ng, Koon-Kwan
• Is Part Of: Journal of cardiovascular magnetic resonance. Volume 18:Issue 1(2016)
• Page Start: 1
• Page End: 9
• Publication Date: 2015-12
• Subjects: Heart failure -- Left ventricular systolic function -- Magnetic resonance spectroscopy -- Myocardial triglyceride content -- Cardiovascular magnetic resonance; Cardiovascular system -- Magnetic resonance imaging -- Periodicals; 616.1207548
• DOI: 10.1186/s12968-016-0228-3
• Languages: English
• ISSNs: 1097-6647

Abstract

Abstract Background Increased myocardial triglyceride (TG) content has been recognized as a risk factor for cardiovascular disease. However, its relation with cardiac function in patients on recovery from acute heart failure (HF) remains unclear. In this cross-sectional study, we sought to investigate the association between myocardial TG content measured on magnetic resonance spectroscopy (1 H-MRS) and left ventricular (LV) function assessed on cardiovascular magnetic resonance (CMR) in patients who were hospitalized with HF. Methods A total of 50 patients who were discharged after hospitalization for acute HF and 21 age- and sex-matched controls were included in the study. Myocardial TG content and LV parameters (function and mass) were measured on a 3.0 T MR scanner. Fatty acid (FA) and unsaturated fatty acid (UFA) content was normalized against water (W) using the LC-Model algorithm. The patient population was dichotomized according to the left ventricular ejection fraction (LVEF, <50 % or ≥ 50 %). Results H-MRS data were available for 48 patients and 21 controls. Of the 48 patients, 25 had a LVEF <50 % (mean, 31.2 %), whereas the remaining 23 had a normal LVEF (mean, 60.2 %). Myocardial UFA/W ratio was found to differ significantly in patients with low LVEF, normal LVEF, and controls (0.79 % vs. 0.21 % vs. 0.14 %, respectively, p = 0.02). The myocardial UFA/TG ratio was associated with LV mass (r = 0.39, p < 0.001) and modestly related to LV end-diastolic volume (LVEDV;r = 0.24, p = 0.039). We also identified negative correlations of the myocardial FA/TG ratio with both LV mass (r = -0.39, p < 0.001) and LVEDV (r = -0.24, p = 0.039). Conclusions As compared with controls, patients who were discharged after hospitalization for acute HF had increased myocardial UFA content; furthermore, UFA was inversely related with LVEF, LV mass and, to a lesser extent, LVEDV. Our study may stimulate further research on the measure of myocardial UFA content by1 H-MRS for outcome prediction. Trial registration ClinicalTrial.gov:NCT02378402 . Registered 27/02/2015