Mechanical effects of left ventricular midwall fibrosis in non-ischemic cardiomyopathy. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Taylor, Robin; Umar, Fraz; Lin, Erica; Ahmed, Amar; Moody, William; Mazur, Wojciech; Stegemann, Berthold; Townend, Jonathan; Steeds, Richard; Leyva, Francisco
• Is Part Of: Journal of cardiovascular magnetic resonance. Volume 18:Issue 1(2016)
• Page Start: 1
• Page End: 8
• Publication Date: 2015-12
• Subjects: Heart failure -- Non ischemic dilated cardiomyopathy -- Mid-wall fibrosis -- Feature-tracking -- Cardiovascular magnetic resonance -- Torsion -- Myocardial deformation; Cardiovascular system -- Magnetic resonance imaging -- Periodicals; 616.1207548
• DOI: 10.1186/s12968-015-0221-2
• Languages: English
• ISSNs: 1097-6647

Abstract

Abstract Background Left ventricular (LV) mid-wall fibrosis (MWF), which occurs in about a quarter of patients with non-ischemic cardiomyopathy (NICM), is associated with high risk of pump failure. The mid LV wall is the site of circumferential myocardial fibers. We sought to determine the effect of MWF on LV myocardial mechanics. Methods Patients with NICM (n = 116; age: 62.8 ± 13.2 years; 67 % male) underwent late gadolinium enhancement cardiovascular magnetic resonance (CMR) and were categorized according to the presence (+) or absence (−) of MWF. Feature tracking (FT) CMR was used to assess myocardial deformation. Results Despite a similar LVEF (24.3 vs 27.5 %, p = 0.20), patients with MWF (32 [24 %]) had lower global circumferential strain (Ɛcc : −6.6 % vs −9.4 %, P = 0.004), but similar longitudinal (Ɛll : −7.6 % vs. −9.4 %, p = 0.053) and radial (Ɛrr : 14.6 % vs. 17.8 %p = 0.18) strain. Compared with − MWF, + MWF was associated with reduced LV systolic, circumferential strain rate (−0.38 ± 0.1 vs −0.56 ± 0.3 s−1, p = 0.005) and peak LV twist (4.65 vs. 6.31°, p = 0.004), as well as rigid LV body rotation (64 % vs 28 %, P <0.001). In addition, +MWF was associated with reduced LV diastolic strain rates (DSRcc : 0.34 vs. 0.46 s−1 ; DSRll : 0.38 vs. 0.50s−1 ; DSRrr : −0.55 vs. −0.75 s−1 ; allp <0.05). Conclusions MWF is associated with reduced LV global circumferential strain, strain rate and torsion. In addition, MWF is associated with rigid LV body rotation and reduced diastolic strain rates. These systolic and diastolic disturbances may be related to the increased risk of pump failure observed in patients with NICM and MWF.