Genetic, hormonal and metabolic aspects of PCOS: an update. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: De Leo, V.; Musacchio, M.; Cappelli, V.; Massaro, M.; Morgante, G.; Petraglia, F.
• Is Part Of: Reproductive biology and endocrinology. Volume 14:Issue 1(2016)
• Page Start: 1
• Page End: 17
• Publication Date: 2016-12
• Subjects: PCOS -- Genetic -- Insulin-resistance -- Hyperandrogenism -- Infertility -- Metformin -- Oral contraceptives -- Myo-inositol; Reproduction -- Periodicals; Generative organs -- Pathophysiology -- Periodicals; Reproduction -- Endocrine aspects -- Periodicals; Endocrine glands -- Diseases -- Periodicals; Embryology -- Periodicals; 571.8
• DOI: 10.1186/s12958-016-0173-x
• Languages: English
• ISSNs: 1477-7827

Abstract

Abstract Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 5–10 % of women of reproductive age. It generally manifests with oligo/anovulatory cycles, hirsutism and polycystic ovaries, together with a considerable prevalence of insulin resistance. Although the aetiology of the syndrome is not completely understood yet, PCOS is considered a multifactorial disorder with various genetic, endocrine and environmental abnormalities. Moreover, PCOS patients have a higher risk of metabolic and cardiovascular diseases and their related morbidity, if compared to the general population.