MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Chu, Shao-Jun; Wang, Ge; Zhang, Peng-Fei; Zhang, Rui; Huang, Yan-Xia; Lu, Yun-Min; Da, Wei; Sun, Qun; Zhang, Jing; Zhu, Jin-Shui
• Is Part Of: Journal of experimental & clinical cancer research. Volume 35:Issue 1(2016)
• Page Start: 1
• Page End: 11
• Publication Date: 2016-12
• Subjects: miRNA-203 -- Growth -- Gastric cancer -- PIBF1 -- Akt; Cancer -- Periodicals; 616.994005
• DOI: 10.1186/s13046-016-0323-1
• Languages: English
• ISSNs: 1756-9966

Abstract

Abstract Background MicroRNAs (miRNAs) have been proved involved in many tumorigenic behaviors including tumor growth. But, the clinical significance and functions of miRNA-203 in gastric cancer (GC) remain elusive. Results Decreased expression of miRNA-203 was correlated with tumor size, poor prognosis and recurrence in GC patients. Overexpression of miR-203 or knockdown of its target progesterone immunomodulatory binding factor 1 (PIBF1) inhibited GC growth in vitro and in vivo, while miR-203 knockdown promoted GC proliferation. In addition, PIBF1 overexpression attenuated the inhibitory effects of miR-203 on GC growth and enhanced that effect on p-Akt expression. Conclusions MiR-203 as a tumor biomarker suppresses GC growth through targeting the PIBF1/Akt signaling, suggesting that it may have the important therapeutic potential for the treatment of GC.