Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cells. (1st May 2019)

• Record Type: Journal Article
• Authors: Charkoftaki, Georgia; Thompson, David C.; Golla, Jaya Prakash; Garcia-Milian, Rolando; Lam, TuKiet T.; Engel, Jasper; Vasiliou, Vasilis
• Is Part Of: Chemico-biological interactions. Volume 304(2019)
• Page Start: 88
• Page End: 96
• Publication Date: 2019-05-01
• Subjects: Biochemistry -- Periodicals; Toxicological chemistry -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biochimie -- Périodiques; Toxicologie biochimique -- Périodiques; 572
• DOI: 10.1016/j.cbi.2019.02.030
• Languages: English
• ISSNs: 0009-2797

Abstract

Highlights: Role of the ALDH1A1 gene in colorectal cancer cells. Integrated network analysis of transcriptomics, proteomics and metabolomics. Down-regulation of the Vitamin A (retinol) metabolism caused by ALDH1A1 suppression. Down-regulation of the cholesterol pathway caused by ALDH1A1 suppression.