Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Jesmin, Subrina; Gando, Satoshi; Wada, Takeshi; Hayakawa, Mineji; Sawamura, Atsushi
• Is Part Of: Journal of intensive care. Volume 4:Issue 1(2016)
• Page Start: 1
• Page End: 3
• Publication Date: 2016-12
• Subjects: Trauma -- Coagulopathy -- Disseminated intravascular coagulation (DIC) -- Activated protein C; Critical care medicine -- Periodicals; Intensive care units -- Periodicals; 616.028
• DOI: 10.1186/s40560-015-0123-2
• Languages: English
• ISSNs: 2052-0492

Abstract

Abstract We hypothesized that activated protein C does not increase in disseminated intravascular coagulation (DIC) after trauma and that the same is true for acute coagulopathy of trauma-shock (ACOTS). Activated protein C levels were prospectively measured in 57 trauma patients: 30 with DIC and 27 without DIC. Normal to more decreased activated protein C levels were observed in DIC patients than in the controls and non-DIC patients. The activated protein C levels in ACOTS patients were similar to those in DIC patients. In conclusion, activated protein C does not increase in either DIC or ACOTS in the early phase of trauma.