Novel antibacterial fibers of amphiphilic N‐halamine polymer prepared by electrospinning. (27th February 2019)

• Record Type: Journal Article
• Authors: Zhu, Chongyi; Chang, Dan; Wang, Xiao; Chai, Danxia; Chen, Lili; Dong, Alideertu; Gao, Ge
• Is Part Of: Polymers for advanced technologies. Volume 30:Number 6(2019)
• Page Start: 1386
• Page End: 1393
• Publication Date: 2019-02-27
• Subjects: amphiphilic polymers -- antibacterial activity -- electrospinning -- N‐halamines -- Short title: antibacterial fibers of amphiphilic N‐halamine polymer.; Polymers -- Periodicals; 668.9
• DOI: 10.1002/pat.4571
• Languages: English
• ISSNs: 1042-7147

Abstract

Abstract : As a significant role in subcategory of halogen antibacterial field, amphiphilic N ‐halamine polymers show a promise as potential antimicrobials having a broad spectrum of microorganisms, long‐term stability, and renewal of their antibacterial properties. By controlling the process parameters, electrospinning has been well recognized as a versatile and effective method being capable of making fibers and could be easily engineered with desired pore size and porosity to enhance the antimicrobial properties. The amphiphilic N ‐halamine P (ADMH‐MMA‐HEMA) terpolymer fibers showed efficient antimicrobial properties against both Gram‐positive and Gram‐negative bacteria within brief contact time. The result meant that the polymer fibers of macromolecular architecture with control of structural parameters such as hydrophobicity/hydrophilicity balance achievement improved antimicrobial activities via electrospinning technique. In vitro cytotoxicity study demonstrated that the polymer was biocompatible. As a result, the integration of amphiphilic antibacterial materials and the electrospinning technique provided us a feasible method to fabricate biocompatible antimicrobial products easily with low manufacturing cost and would be applied in many promising application areas.