2‐Alkynylaryl Aldehydes (Enynals) in Organic Synthesis. Issue 9 (14th March 2019)

• Record Type: Journal Article
• Authors: Li, Longlong; Huang, Dayun; Shi, Chengjin; Yan, Guobing
• Is Part Of: Advanced synthesis & catalysis. Volume 361:Issue 9(2019)
• Page Start: 1958
• Page End: 1984
• Publication Date: 2019-03-14
• Subjects: 2-alkynylaryl aldehydes -- electrophiles -- mechanism -- multifunctionality -- nucleophiles; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201801472
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: 2‐Alkynylaryl aldehydes are widely used in organic reactions. Their great success is rooted in their multiple functional groups. This review will focus on five kinds of triggered mechanisms: (i) aldehydes as electrophiles, (ii) alkynes as electrophiles, (iii) 5‐ exo ‐ dig reactions, (iv) 6‐ endo ‐ dig intermediates, and (v) imine intermediates via 6‐ endo ‐ dig cyclizations. Reactions with alkenes, alkynes, arenes, malononitrile, alcohols, amines, amides, acetal, ketones, hydrazine, iodobenzene, azides, carbenes, arylboronic acids, amino acids etc. will be discussed. We hope that this review will pronote future research in this area. Abstract :