Identification of ANLN as ETV6 partner gene in recurrent t(7;12)(p15;p13): a possible role of deregulated ANLN expression in leukemogenesis. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Campregher, Paulo; Pereira, Welbert; Lisboa, Bianca; Puga, Renato; Helman, Ricardo; Miyagi, Mariana; da Mata, Evelyn; Datoguia, Tarcila; Velloso, Elvira; Bacal, Nydia; Ross, Jeffrey; Ali, Siraj; Miller, Vincent; Costa, Fernando; Hamerschlak, Nelson; Santos, Fabio
• Is Part Of: Molecular cancer. Volume 14:Issue 1(2015)
• Page Start: 1
• Page End: 4
• Publication Date: 2015-12
• Subjects: Leukemia -- Myeloid -- Acute -- Gene fusion -- Translocation -- Genetic; Cancer -- Molecular aspects -- Periodicals; 616.994
• DOI: 10.1186/s12943-015-0471-5
• Languages: English
• ISSNs: 1476-4598

Abstract

Abstract TheETV6 gene encodes an ETS family transcription factor that is involved in a myriad of chromosomal rearrangements found in hematological malignancies and other neoplasms. A recurrentETV6 translocation, previously described in patients with acute myeloid leukemia (AML) (Genes Chromosomes Cancer 51:328–337, 2012, Leuk Res 35:e212-214, 2011), whose partner has not been identified is t(7;12)(p15;p13). We herein report that the t(7;12)(p15;p13) fusesETV6 toANLN, a gene not previously implicated in the pathogenesis of hematological malignancies, and we demonstrate that this translocation leads to high expression of the fusion transcript in the myeloid and lymphoid lineages.