Correlations of serum cystatin C and glomerular filtration rate with vascular lesions and severity in acute coronary syndrome. Issue 1 (December 2017)

• Record Type: Journal Article
• Authors: Zhang, Jinjin; Wu, Xianhao; Gao, Peizhen; Yan, Pingping
• Is Part Of: BMC cardiovascular disorders. Volume 17:Issue 1(2017)
• Page Start: 1
• Page End: 9
• Publication Date: 2017-12
• Subjects: Acute coronary syndrome -- Serum cystatin C -- Glomerular filtration rate -- Correlation study; Cardiovascular system -- Diseases -- Periodicals; 616.12005
• DOI: 10.1186/s12872-017-0483-8
• Languages: English
• ISSNs: 1471-2261

Abstract

Abstract Background The aim of this study was to evaluate the predictive value of cystatin C (CysC) and estimated glomerular filtration rate (eGFR) regarding vascular lesions and their severity in patients with acute coronary syndrome (ACS). Methods According to the results of coronary angiography, 195 ACS patients were divided into a single-vascular-lesion group (91 cases), a dual-vascular-lesion group (67 cases), and a multiple-vascular-lesion group (37 cases) to assess the severity of coronary artery disease according to Gensini scores and to analyze the correlations of CysC and eGFR level with vascular lesions and severity in ACS patients. Results Intergroup comparisons of univariate and multivariate regression analyses showed that CysC was positively correlated with vascular lesions (P < 0.05), but eGFR showed no correlation. Regarding the severity of vascular lesions, CysC was positively correlated with Gensini score (Pearson's correlation coefficientr = 0.1811, P < 0.05), but eGFR was not correlated (P > 0.05). Conclusions Serum CysC levels could reflect the severity of vascular lesions in ACS patients, and a high CysC level had predictive value regarding the severity of vascular lesions in ACS.