Cellular therapies for the endometrium: An update. (25th March 2019)

• Record Type: Journal Article
• Authors: Queckbörner, Suzanna; Davies, Lindsay C.; von Grothusen, Carolina; Santamaria, Xavier; Simón, Carlos; Gemzell‐Danielsson, Kristina
• Is Part Of: Acta obstetricia et gynecologica Scandinavica. Volume 98:Number 5(2019)
• Page Start: 672
• Page End: 677
• Publication Date: 2019-03-25
• Subjects: Asherman's syndrome -- cell therapy -- endometrial disease -- female infertility; Gynecology -- Periodicals; Pregnancy -- Periodicals; Obstetrics -- Periodicals; 618.05
• DOI: 10.1111/aogs.13598
• Languages: English
• ISSNs: 0001-6349

Abstract

Abstract: An update on the current state of endometrial cell therapies in terms of cell types, mechanisms of action, delivery, safety, regulatory frameworks and future perspectives. This review focuses on clinical trials using angiogenesis‐promoting therapies and stromal therapies piloted in the last 10 years for alleviating Asherman's syndrome and long‐term infertility. All studies present promising preliminary results, indicating increased endometrial thickness and resumed menstruation. Further characterization of individual cell products, their mode of action and larger clinical trials will be essential to establishing cell therapy as a viable option for the treatment of infertility and fertility preservation.