Preparation, properties and in vitro cellular response of multi-walled carbon nanotubes/bioactive glass/poly(etheretherketone) biocomposite for bone tissue engineering. Issue 8 (24th May 2019)

• Record Type: Journal Article
• Authors: Cao, Jianfei; Lu, Yue; Chen, Hechun; Zhang, Lifang; Xiong, Chengdong
• Is Part Of: International journal of polymeric materials. Volume 68:Issue 8(2019)
• Page Start: 433
• Page End: 441
• Publication Date: 2019-05-24
• Subjects: Biocompatibility -- biocomposite -- cellular response -- mechanical properties -- poly(etheretherketone); Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2018.1455679
• Languages: English
• ISSNs: 0091-4037

Abstract

ABSTRACT: Desired bone repair biomaterial must have good biocompatibility and suitable mechanical properties that are equivalent to those of human bones. In this study, multi-walled carbon nanotubes (MWCNTS) was designed to incorporate into bioactive glass/poly(etheretherketone) to fabricate a composite of multi-walled carbon nanotubes/bioactive glass/poly(etheretherketone) (MWCNTS/BG/PEEK) through a compounding and injection-molding process. The microstructures, mechanical properties, thermal stability and bioactivity of the ternary biocomposite, as well as preliminary cell responses of MC3T3-E1 osteoblast cells to this biomaterial, were investigated. The mechanical performance of ternary MWCNTS/BG/PEEK composite was vastly superior to binary BG/PEEK composite. More importantly, cell culture tests showed that cell adhesion, viability and differentiation of MC3T3-E1 cells were significantly promoted on the MWCNTS/BG/PEEK composite. Moreover, it was found that MWCNTS in composite further promoted cell metabolic vitality and osteogenic differentiation of osteoblast cells. Hence, this MWCNTS/BG/PEEK biomaterial may be used as a promising bone graft scaffold in dental and orthopedic applications. GRAPHICAL ABSTRACT: