Cancer-Associated Fibroblasts Induce Epithelial-Mesenchymal Transition in Endometrial Cancer Cells by Regulating Pituitary Tumor Transforming Gene. (16th March 2019)

• Record Type: Journal Article
• Authors: Wang, Xiaoyun; Sun, Xiwen; Mu, Lin; Chen, Wei
• Is Part Of: Cancer investigation. Volume 37:Number 3(2019)
• Page Start: 134
• Page End: 143
• Publication Date: 2019-03-16
• Subjects: Endometrial cancer -- Cancer-associated fibroblasts -- Epithelial-mesenchymal transition -- Pituitary tumor transforming gene; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2019.1575969
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: Cancer-associated fibroblasts (CAFs) play an important role in the development and progression of cancer by inducing epithelial-mesenchymal transition (EMT). In this study, we investigated the role of CAFs in endometrial cancer (EC) cells. We found that the pituitary tumor transforming gene ( PTTG ) expression was significantly increased in EC cell lines compared to normal human endometrial epithelial cells. Furthermore, CAFs could induce PTTG over-expression and increase EC cell invasion and migration in vitro . In addition, CAFs also induced EMT in EC cells. This study demonstrated that CAFs induced EMT in endometrial cancer cells by regulating PTTG .