Prospective observational study to evaluate the efficacy and safety of the pollen extract Sérélys® in the management of women with menopausal symptoms. (3rd April 2019)

• Record Type: Journal Article
• Authors: Fait, Tomas; Sailer, Manuela; Regidor, Pedro-Antonio
• Is Part Of: Gynecological endocrinology. Volume 35:Number 4(2019)
• Page Start: 360
• Page End: 363
• Publication Date: 2019-04-03
• Subjects: Pollen extract -- menopause -- non-estrogenic activity; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.1080/09513590.2018.1538347
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Safety concerns or contraindications to the use of hormones have resulted in a rise of the use of herbal medicinal products for the management of menopausal symptoms. The pollen extract Sérélys ® represents, due to its ingredients and mode of action, a new and innovative alternative for the management of these symptoms. The aim of the present study was to demonstrate the efficacy and safety of Sérélys ® . A prospective, open, observational, and multicentre study was performed on 104 menopausal women. The patients received over 3 months the pollen extract Sérélys ® containing the extracts PI82 and GC Fem in a dosage of twice 160 mg extract and 5 mg vitamin E. Using a validated menopausal rating score, the improvement of menopausal symptoms was recorded. A significant decrease of different menopausal symptoms was observed between the starting point of the study and after 12 weeks ( p < .0001). Hot flashes were reduced by 48.5%, sleep disturbance by 50.1%, depressive mood by 51.2%, irritability by 47.9%, fatigue by 47.8%, vaginal dryness by 39.63% and muscles and joint pain by 27.4%. The pollen extract Sérélys ® reduced significant menopausal symptoms showing a very low side effect profile.