CCR4 Expression in Tumor-Infiltrating Regulatory T Cells in Patients with Squamous Cell Carcinoma of the Lung: A Prognostic Factor for Relapse and Survival. (16th March 2019)

• Record Type: Journal Article
• Authors: Asai, Nobuhiro; Kubo, Akihito; Suzuki, Susumu; Murotani, Kenta; Numanami, Hiroki; Yoshikawa, Kazuhiro; Ueda, Ryuzo; Yamaguchi, Etsuro
• Is Part Of: Cancer investigation. Volume 37:Number 3(2019)
• Page Start: 163
• Page End: 173
• Publication Date: 2019-03-16
• Subjects: Non-small cell lung cancer -- Squamous cell carcinoma of the lung -- Regulatory T cell -- CCR4 -- Foxp3; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2019.1582848
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: To clarify the prognostic impact of tumor-infiltrating effector regulatory T cells (eTregs) in non-small cell lung cancer (NSCLC), eTregs were evaluated by immunohistochemical detection of CCR4 and Foxp3 in 108 consecutive surgical NSCLC tumors. Multivariate analysis showed that a high ratio of CCR4 + eTregs to total Tregs (≥40%) was the only independent risk factor for relapse-free survival (odds ratio [OR]: 6.54, 95% confidence interval: 1.67–25.7, p = .007) and overall survival (OR: 3.76, p = .037) in lung squamous cell carcinoma (SqCC). These results highlight the prognostic importance of the balance of tumor-infiltrating Tregs in resected lung SqCC.