Cytokine-induced killer cells co-cultured with non-cell derived targeting peptide-loaded dendritic cells induce a specific antitumor response. Issue 5 (4th May 2019)

• Record Type: Journal Article
• Authors: Liu, Cuijuan; Cui, Xueyuan; Zhou, Dayong; Li, Chunlin; Zhao, Mengya; Jin, Yaqing; Ding, Chen; Zhu, Yimin
• Is Part Of: Cancer biology & therapy. Volume 20:Issue 5(2019)
• Page Start: 720
• Page End: 728
• Publication Date: 2019-05-04
• Subjects: Dendritic cells -- cytokine-induced killer cells -- cancer -- peptide -- immunotherapy; 616.99406
• DOI: 10.1080/15384047.2018.1564561
• Languages: English
• ISSNs: 1538-4047

Abstract

ABSTRACT: Cancer is a severe lethal disease. Currently, immunotherapy has become an effective alternative therapeutic approach for cancers. Cytokine-induced killer (CIK) cells have a higher proliferation rate, increased efficacy with few side-effects, and non-MHC-restricted killing after co-culturing with dendritic cells (DCs). Therefore, it has been widely studied and applied in the treatment of cancers. In our study, we explored the antitumor effects of CIK cells co-culturing with DCs pulsed with non-cell derived targeting peptides, which could specifically bind to certain tumor cells. Our results indicated that targeting peptide-loaded DCs could enhance the differentiation and cytotoxicity of CIK cells. Moreover, CIK cells, which were treated with specific targeting peptide-loaded DCs, could effectively and specifically kill tumor cells in vitro and in vivo, as long as tumor cells were pre-coated with the specific binding peptides. In conclusion, targeting peptides could guide DC-CIK to effectively and specifically kill tumor cells which were pre-coated with these targeting peptides and non-cell derived targeting peptide-loaded-DC-CIK may work as a novel means for cancer therapy.