Pd(ii)/Ag(i)-Cocatalyzed ortho direct arylation of O-phenylcarbamates with pinacol aryl boronates. Issue 9 (14th March 2019)

• Record Type: Journal Article
• Authors: Ma, Huijun; Wang, Tao; Gao, Chenying; Li, Guangshen; Zhang, Minghao; Wang, Qifeng
• Is Part Of: Organic chemistry frontiers. Volume 6:Issue 9(2019)
• Page Start: 1409
• Page End: 1413
• Publication Date: 2019-03-14
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c9qo00227h
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Ortho direct arylation of O -phenyl carbamates using aryl boronates as coupling partners has been realized for the first time using Pd(OAc)2 and AgOAc as co-catalyst. Abstract : Ortho direct arylation of O -phenylcarbamates using aryl boronates as coupling partners has been realized for the first time in the literature. A mechanistic investigation showed that the Wheland intermediate with ortho C–H remaining after carbopalladation was the key intermediate for further transformation. Isotope competition experiments indicated that C–H cleavage was not involved in the rate-determining step.