Amygdalar volume and violent ideation in a sample at clinical high-risk for psychosis. (30th May 2019)

• Record Type: Journal Article
• Authors: Feng, Xinyang; Provenzano, Frank; Appelbaum, Paul S.; Masucci, Michael D.; Brucato, Gary; Lieberman, Jeffrey A.; Girgis, Ragy R.
• Is Part Of: Psychiatry research. Volume 287(2019)
• Page Start: 60
• Page End: 62
• Publication Date: 2019-05-30
• Subjects: Violence -- Ideation -- Psychosis -- Clinical high-risk -- Amygdala -- MRI; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2019.04.003
• Languages: English
• ISSNs: 0925-4927

Abstract

Highlights: We performed amygdalar surface morphometry analysis on MRI scans from 70 CHR individuals, 21 of whom had violent ideation, 49 of whom did not. CHR individuals with violent ideation have abnormal and asymmetric amygdalar volumes. These data suggest some commonalities in the genesis of violence and aggression among clinical populations, as well as that there may be specific neurobiological links between violence and psychosis. Abstract: We previously demonstrated that violent ideation predicts both violent acts and eventual progression to syndromal psychosis in individuals at clinical high-risk for psychosis (CHR). We performed amygdalar surface morphometry analysis on MRI scans from 70 CHR individuals, 21 of whom had violent ideation, 49 of whom did not. CHR individuals with violent ideation have abnormal and asymmetric amygdalar volumes. These data suggest some commonalities in the genesis of violence and aggression among clinical populations, as well as that there may be specific neurobiological links between violence and psychosis.