The accuracy of incremental pre-operative breast MRI findings – Concordance with histopathology in the Swedish randomized multicenter POMB trial. Issue 114 (May 2019)

• Record Type: Journal Article
• Authors: Karlsson, Anders; Gonzalez, Virginia; Jaraj, Sara Jonmarker; Bottai, Matteo; Sandelin, Kerstin; Arver, Brita; Eriksson, Staffan
• Is Part Of: European journal of radiology. Issue 114(2019)
• Page Start: 185
• Page End: 191
• Publication Date: 2019-05
• Subjects: Breast cancer -- Pre-operative breast MRI -- Breast conserving surgery; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2019.03.005
• Languages: English
• ISSNs: 0720-048X

Abstract

Abstract: Purpose: The Pre-Operative MRI of the Breast (POMB) trial was a randomized, prospective, multicenter trial evaluating the impact of pre-operative breast MRI on treatment regimens and short-term surgical outcomes in women up to 56 years of age with breast cancer. The purpose of this study was to evaluate the performance of pre-operative breast MRI in the POMB trial with respect to incremental MRI findings - over conventional breast imaging methods – and their concordance with histopathology. Patients and methods: Two-hundred and ten patients (n = 210) participating in the POMB trial underwent pre-operative breast MRI at two Swedish breast units. Positive predictive values ( PPV ) for the incremental MRI findings were calculated for three subgroups of patients with: 1. alteration/alterations of treatment plan; 2. no alteration of treatment plan; and, 3. MRI-related conversion from BCS to mastectomy. Area under the receiver operating characteristic curve (AUC) was calculated using in-breast BI-RADS based ratings for the whole MRI group. Results: After exclusions a total number of 99 incremental findings in 78 patients were eligible for statistical analysis resulting in a PPV = 74%: (95% CI 60–84%) in 39 patients with MRI related alterations of initial treatment plans and 27%: (95% CI 14–44%) in 39 patients without. Positive predictive values of incremental findings decisive for specific treatment alteration/s were 83% (95% CI 68–92%) in patients with any alteration of initial treatment plans and 91% (95% CI 70–98%) for patients (n = 20/22) with conversion from breast conserving surgery to mastectomy. The empirical AUC for the incremental findings in the whole MRI group was 85% (95% CI 78–91%). Conclusion: Breast MRI, performed and evaluated together with conventional breast imaging methods can provide relevant information at a high degree of accuracy in the pre-operative setting.