Providing lipid-based nutrient supplement during pregnancy does not reduce the risk of maternal P falciparum parasitaemia and reproductive tract infections: a randomised controlled trial. Issue 1 (December 2017)

• Record Type: Journal Article
• Authors: Nkhoma, Minyanga; Ashorn, Per; Ashorn, Ulla; Dewey, Kathryn; Gondwe, Austrida; Mbotwa, John; Rogerson, Stephen; Taylor, Steve; Maleta, Kenneth
• Is Part Of: BMC pregnancy and childbirth. Volume 17:Issue 1(2017)
• Page Start: 1
• Page End: 8
• Publication Date: 2017-12
• Subjects: Micronutrients -- Pregnancy -- Plasmodium falciparum -- Reproductive tract infections -- Urinary tract infection; Pregnancy -- Periodicals; Childbirth -- Periodicals; Obstetrics -- Periodicals; 618.2005
• DOI: 10.1186/s12884-016-1215-2
• Languages: English
• ISSNs: 1471-2393

Abstract

Abstract Background Maternal infections are associated with maternal and foetal adverse outcomes. Nutrient supplementation during pregnancy may reduce the occurrence of infections by improving maternal immunity. We aimed to investigate the impact of small-quantity lipid-based nutrient supplement (SQ-LNS) on the occurrence ofPlasmodium falciparum parasitaemia during pregnancy and trichomoniasis, vaginal candidiasis and urinary tract infection (UTI) after delivery. Methods Pregnant Malawian women enrolled in the iLiNS-DYAD trial receiving daily supplementation with SQ-LNS, multiple micronutrients (MMN) or iron & folic acid (IFA) from <20 gestation weeks (gw) were assessed forP. falciparum parasitaemia at 32 gw using rapid diagnostic testing (RDT), at 36 gw using polymerase chain reaction (PCR) and at delivery using both RDT and PCR; and at one week after delivery for trichomoniasis and vaginal candidiasis using wet mount microscopy and for UTI using urine dipstick analysis. The prevalence of each infection by intervention group was estimated at the prescribed time points and the global null hypothesis was tested using logistic regression. Adjusted analyses were performed using preselected covariates. Results The prevalence ofP. falciparum parasitaemia was 10.7% at 32 gw, 9% at 36 gw, and 8.3% by RDT and 20.2% by PCR at delivery. After delivery the prevalence of trichomoniasis was 10.5%, vaginal candidiasis was 0.5%, and UTI was 3.1%. There were no differences between intervention groups in the prevalence of any of the infections. Conclusion In this population, SQ-LNS did not influence the occurrence of maternalP. falciparum parasitaemia, trichomoniasis, vaginal candidiasis or UTI. Trial registration Identifier:NCT01239693 (10 November 2010).