A ratiometric flavone-based fluorescent probe for hypochlorous acid detection with large Stokes shift and long-wavelength emission. (July 2019)

• Record Type: Journal Article
• Authors: He, Long; Zhang, Yun; Xiong, Haiqing; Wang, Jingpei; Geng, Yani; Wang, Benhua; Wang, Yangang; Yang, Zhaoguang; Song, Xiangzhi
• Is Part Of: Dyes and pigments. Volume 166(2019)
• Page Start: 390
• Page End: 394
• Publication Date: 2019-07
• Subjects: Ratiometric -- Flavone-based -- Long-wavelength -- Large Stokes shift; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2019.03.029
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: A ratiometric fluorescent probe, FPT, was designed and synthesized for the selective and sensitive detection of hypochlorous acid (HClO) based on a flavone derivative under a single wavelength excitation. The addition of HClO to the solution ofFPT induced a distinct fluorescence color change from orange to green. ProbeFPT was successfully used to detect and image intracellular HClO in living zebra fish in a ratiometric manner. Graphical abstract: A flavone-based ratiometric fluorescent probe with large Stokes shift and long-wavelength emission for the sensitive and selective detection of hypochlorous acid has been developed. The application of this probe for imaging hypochlorous acid in zebra fish was successfully demonstrated under a single-wavelength excitation.Image 1 Highlights: This probe had large Stokes shift. This probe displayed a ratio fluorescence I524 nm /I586 nm with a single-wavelength excitation at 380 nm. This probe had long-wavelength emission.