Association of physical activity and fitness with S-Klotho plasma levels in middle-aged sedentary adults: The FIT-AGEING study. (May 2019)

• Record Type: Journal Article
• Authors: Amaro-Gahete, Francisco J.; de-la-O, Alejandro; Jurado-Fasoli, Lucas; Gutiérrez, Ángel; Ruiz, Jonatan R.; Castillo, Manuel J.
• Is Part Of: Maturitas. Volume 123(2019)
• Page Start: 25
• Page End: 31
• Publication Date: 2019-05
• Subjects: S-Klotho shed form of the α-Klotho gene -- LPA light physical activity time -- MPA moderate physical activity time -- VPA vigorous activity time -- MVPA moderate-vigorous physical activity time -- VO2max maximal oxygen uptake -- RPE rating of perceived exertion -- BMI body mass index -- FMI fat mass index -- LMI lean mass index; VO2max -- Peak torque -- Hand grip -- Longevity -- Ageing; Climacteric -- Periodicals; Menopause -- Periodicals; Climacteric -- Periodicals; Geriatrics -- Periodicals; Menopause -- Periodicals; Middle Aged -- Periodicals; Climatère -- Périodiques; Ménopause -- Périodiques; Climacterium; Climacteric; Menopause; Electronic journals; Periodicals; 612.66
• DOI: 10.1016/j.maturitas.2019.02.001
• Languages: English
• ISSNs: 0378-5122

Abstract

Highlights: Physical fitness is associated with S-Klotho plasma levels in middle-aged sedentary men and women. The above-mentioned association could be highly dependent on lean mass. S-Klotho protein could mediate the relationship between physical fitness and health improvements during the ageing process. Abstract: Objectives: To determine the association between physical activity and physical fitness levels (i.e. cardiorespiratory fitness and muscular strength) and the shed form of the α-Klotho gene (S-Klotho plasma levels) in middle-aged sedentary adults. Study design and main outcome measures: A total of 74 middle-aged sedentary adults (52.7% women; 53.7 ± 5.1 years old) were enrolled in the FIT-AGEING study. Physical activity and sedentary time were assessed with a wrist-worn accelerometer. Maximal oxygen uptake (VO2 max) was determined by a maximum treadmill test using indirect calorimetry. Lower- and upper-body muscular strength were assessed by an isokinetic strength test and by the hand grip strength test, respectively. The S-Klotho plasma levels were measured in the EDTA plasma using a solid-phase sandwich enzyme-linked immunosorbent assay. Results: Based on the principal-component analysis, overall physical activity, moderate and vigorous physical activity levels, and sedentary time (as outcomes included in the 'sedentary time and physical activity' category) explained a total of 17.5% of the cumulative variance in S-Klotho plasma levels, while extension peak torque, hand grip strength, and maximal oxygen uptake (as outcomes included in the 'physical fitness' category) explained a total of 15.5% of the cumulative variance in S-Klotho plasma levels. Based on the loading of variables in these 2 categories, the percentage of the cumulative variance in S-Klotho plasma level explained was 28.9%s; this reached 33.0% of cumulative variance when sex was included in the model. Conclusions: In summary, our results indicate that physical activity and physical fitness levels are associated with S-Klotho plasma levels in middle-aged sedentary adults. Therefore, the S-Klotho protein could be a key factor in the relationship between physical activity and physical fitness and health improvements during the ageing process.