Increased IL-17 and/or IFN-γ producing T-cell subsets in gut mucosa of long-term-treated HIV-1-infected women. (15th March 2019)

• Record Type: Journal Article
• Authors: d'Ettorre, Gabriella; Borrazzo, Cristian; Pinacchio, Claudia; Santinelli, Letizia; Cavallari, Eugenio N.; Statzu, Maura; Fanello, Gianfranco; Ceccarelli, Giancarlo; Antonelli, Guido; Vullo, Vincenzo; Mastroianni, Claudio M.; Scagnolari, Carolina
• Is Part Of: AIDS. Volume 33:Number 4(2019)
• Publication Date: 2019-03-15
• Subjects: gut -- HIV -- sex -- Tc1 -- Tc17 -- Th1 -- Th17; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome; AIDS (Disease); Periodicals; Periodicals; 616.9792005
• DOI: 10.1097/QAD.0000000000002122
• Languages: English
• ISSNs: 0269-9370

Abstract

Abstract : Objective: The influence of sex on gut mucosal T-cell response in HIV-1 infection remains largely unknown. We explored whether the frequencies of interferon-γ and/or IL-17 producing naive, T central memory and T effector memory (TEM) CD4 + (Th1, Th17) and CD8 + T (Tc1, Tc17) cells measured in gut and peripheral districts differed between female and male HIV-1-infected patients. Methods: Thirty long-term-treated HIV-1-infected individuals were enrolled. The frequencies of Th1, Th17, Tc1, Tc17-cell subsets (single and double) were evaluated by multiparametric flow cytometry in lamina propria lymphocytes and peripheral blood mononuclear cells (PBMC). Results: A sex-based pattern was recorded in the differences of Th1, Th17, Tc1, Tc17-cell subset (single and double) frequencies between gut and peripheral blood. Female patients had stronger alterations in the gut mucosal T-cell repertoire, especially increased Th1, Th17, and Th1/Th17-cell subset frequencies, compared with the blood district than their male counterparts. Higher naive Tc1, Tc17, Tc1/Tc17, TEM Tc17, and TEM Tc1/Tc17 levels were also recorded in the gut mucosa than in the PBMC of HIV-1-infected women. Males and females also differed in their gut T-cell response, with women being characterized by higher Th1, Th17, Tc1, Tc17, and Th1/Th17 cells subset levels than men. By contrast, only TEM Th1/Th17 and TEM Tc17 in PBMC differed between males and females. Conclusion: Sex-based differences observed in the gut T-cell response of HIV-1-infected patients might contribute to the disease dimorphism.