Association between osteoarthritis and increased risk of dementia: A systemic review and meta-analysis. Issue 10 (March 2019)

• Record Type: Journal Article
• Authors: Weber, Adrian; Mak, Shing hung; Berenbaum, Francis; Sellam, Jérémie; Zheng, Yong-Ping; Han, Yifan; Wen, Chunyi
• Other Names: Zhan. Yiqiang section editor.
• Is Part Of: Medicine. Volume 98:Issue 10(2019)
• Publication Date: 2019-03
• Subjects: dementia -- meta-analysis -- osteoarthritis -- systematic review; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000014355
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Objective: To investigate the possible association between osteoarthritis (OA) and the risk of dementia. Methods: Cohort, case-control, and cross-sectional studies were obtained from wide literature search up to 20 April 2018 from following electronic databases: PubMed, Embase, Cochrane, using the MeSH terms: "osteoarthritis" AND "dementia". The literature search was then expanded to congress abstracts. After screening and selection of relevant studies by two investigators, data was extracted. Estimates were then calculated using a random-effect size model. Sensitivity-analysis was conducted for gender and age adjusted studies and pooled for studies with STROBE quality assessment score ≥75%. Publication bias was assessed by Funnel plot. Analyses were performed using Data Analysis and Statistical Software Version 14.2. Results: Nearly 1549 publication references were initially retrieved. Twenty-six publications were checked with full-text. Six observational studies with 388, 252 individuals were included. OA was associated with a significantly increased risk for dementia (OR = 1.20; 95% confidence interval (CI), 1.03–1.39, I 2 = 95.6%, P < .05). After pooling the studies with adjustment of age and gender, the risk increased (OR 1.36; 95% CI, 1.22–1.51, I 2 = 75.6%, P < .0001). After pooling the study with a STROBE Quality score ≥75% the risk for dementia was slightly increased (OR 1.33; 95% CI, 1.17–1.5, I 2 = 93.5%, p < 0.0001). Conclusions: There is an association between osteoarthritis and the risk of dementia. This meta-analysis does not provide causality. Further prospective cohort studies are needed to clarify, if knee-, hip-, or hand-OA are independent risk factors for Alzheimer's disease and vascular dementia. Abstract : Supplemental Digital Content is available in the text