Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Ahmad, Shafqat; Zhao, Wei; Renström, Frida; Rasheed, Asif; Samuel, Maria; Zaidi, Mozzam; Shah, Nabi; Mallick, Nadeem; Zaman, Khan; Ishaq, Mohammad; Rasheed, Syed; Memon, Fazal-ur-Rheman; Hanif, Bashir; Lakhani, Muhammad; Ahmed, Faisal; Kazmi, Shahana; Frossard, Philippe; Franks, Paul; Saleheen, Danish
• Is Part Of: BMC medical genetics. Volume 16:Issue 1(2015)
• Page Start: 1
• Page End: 11
• Publication Date: 2015-12
• Subjects: Obesity -- Physical activity -- Smoking -- Genetic susceptibility -- Gene-lifestyle interactions; Medical genetics -- Periodicals; 616.04205
• DOI: 10.1186/s12881-015-0259-x
• Languages: English
• ISSNs: 1471-2350

Abstract

Abstract Background Multiple genetic variants have been reliably associated with obesity-related traits in Europeans, but little is known about their associations and interactions with lifestyle factors in South Asians. Methods In 16, 157 Pakistani adults (8232 controls; 7925 diagnosed with myocardial infarction [MI]) enrolled in the PROMIS Study, we tested whether: a) BMI-associated loci, individually or in aggregate (as a genetic risk score - GRS), are associated with BMI; b) physical activity and smoking modify the association of these loci with BMI. Analyses were adjusted for age, age2, sex, MI (yes/no), and population substructure. Results Of 95 SNPs studied here, 73 showed directionally consistent effects on BMI as reported in Europeans. Each additional BMI-raising allele of the GRS was associated with 0.04 (SE = 0.01) kg/m2 higher BMI (P = 4.5 × 10−14 ). We observed nominal evidence of interactions ofCLIP1 rs11583200 (P interaction = 0.014), CADM2 rs13078960 (P interaction = 0.037) andGALNT10 rs7715256 (P interaction = 0.048) with physical activity, andPTBP2 rs11165643 (P interaction = 0.045), HIP1 rs1167827 (P interaction = 0.015), C6orf106 rs205262 (P interaction = 0.032) andGRID1 rs7899106 (P interaction = 0.043) with smoking on BMI. Conclusions Most BMI-associated loci have directionally consistent effects on BMI in Pakistanis and Europeans. There were suggestive interactions of established BMI-related SNPs with smoking or physical activity.