Association of ADIPOQ gene with type 2 diabetes and related phenotypes in African American men and women: the Jackson Heart Study. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Davis, Sharon; Xu, Ruihua; Gebreab, Samson; Riestra, Pia; Gaye, Amadou; Khan, Rumana; Wilson, James; Bidulescu, Aurelian
• Is Part Of: BMC genetics. Volume 16:Issue 1(2015)
• Page Start: 1
• Page End: 13
• Publication Date: 2015-12
• Subjects: Adiponectin -- Type 2 diabetes -- ADIPOQ gene -- African Americans; Genetics -- Periodicals; 576.505
• DOI: 10.1186/s12863-015-0319-4
• Languages: English
• ISSNs: 1471-2156

Abstract

Abstract Background African Americans experience disproportionately higher prevalence of type 2 diabetes and related risk factors. Little research has been done on the association ofADIPOQ gene on type 2 diabetes, plasma adiponectin, blood glucose, HOMA-IR and body mass index (BMI) in African Americans. The objective of our research was to assess such associations with selected SNPs. The study included a sample of 3, 020 men and women from the Jackson Heart Study who hadADIPOQ genotyping information. Unadjusted and adjusted regression models with covariates were used with type 2 diabetes and related phenotypes as the outcome stratified by sex. Results There was no association between selectedADIPOQ SNPs with type 2 diabetes, blood glucose, or BMI in men or women. There was a significant association between variant rs16861205 and lower adiponectin in women with minor allele A in the fully adjusted model (β(SE)p = −.13(0.05), 0.003). There was also a significant association with variant rs7627128 and lower HOMA-IR among men with minor allele A in the fully adjusted model (β(SE)p = −0.74(0.20), 0.0002). Conclusions These findings represent new insights regarding the association ofADIPOQ gene and type 2 diabetes and related phenotypes in African American men and women.