Carbon multi‐electrode arrays as peripheral nerve interface for neural recording and nerve stimulation. Issue 1 (29th March 2019)

• Record Type: Journal Article
• Authors: Zhang, Xinuo; Chen, Chaoyang; Ni, Guoxin; Hai, Yong; Chen, Biao; Zhou, Yang; Zhang, Boshen; Chen, Gui; Cheng, Mark Ming‐Cheng
• Is Part Of: Medical devices & sensors. Volume 2:Issue 1(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-03-29
• Subjects: carbon -- compound muscle action potential -- electromyogram -- microelectrode array -- nerve stimulation -- peripheral nerve interface -- platinum electrode; Medical instruments and apparatus -- Periodicals; Biomedical engineering -- Periodicals; Electronic journals; Periodicals; 610.28
• DOI: 10.1002/mds3.10026
• Languages: English
• ISSNs: 2573-802X

Abstract

Abstract: Microelectrodes are widely used as a peripheral nerve interface (PNI) to connect the peripheral nerve to a computer for restoration of sensorimotor function and bionic device motion control. Materials used for implantable microelectrode are still facing the challenges from biocompatibility and bio‐fidelity in neural signal recording and nerve stimulating. In this study, we report that carbon multi‐electrode arrays (cMEAs) can be fabricated using carbon ink, micro resin dimethylsiloxane and 3D printing technology and ink for PNI. In vitro cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) demonstrated that the cMEAs have higher charge storage capacity (CSC) and less impedance than conventional platinum (Pt) electrode. In vivo studies using an animal model demonstrated that cMEAs are more effective in stimulating the nerve to elicit muscle contraction and recording compound muscle action potentials (CMAPs) than the Pt electrode. The cMEAs has lower stimulating threshold to elicit muscle activity, higher signal‐to‐noise (SNR) in CMAP. Our studies demonstrate that cMEAs can be an advanced healthcare materials in nerve signal nerve stimulation for PNI and muscle bioelectrical signal recording for peripheral muscle interface (PMI).